Synthesis and Pharmacological Evaluation of Thiazolidinone Derivatives as Anticancer Agents

Abstract

By cyclocondensing azomethines of type 2a–m with thioglycolic acid and thiolactic acid, respectively, 4-thiazolidinones of types 3a–m and 4a–m were created. The azomethines 2a–m are produced via the reaction of 2-chloro-6-methylquinoline-3-carboxaldehyde with arylamines. The products' ability to suppress the development of several microorganisms in vitro was assessed. 94.45% of the synthesized chemical had biological screening activity, and several of the compounds had strong antibacterial activity, including videlicet. Of the compounds, 36.12% were shown to be more effective against E. coli than the common medication Penicillin. It was shown that 44.45% of the synthesized compounds were more effective against A. niger than the common medication Greseofulvin. 8.34% of the substances were more effective against B. megaterium than the common medications, ampicilin, chloramphenicol, and penicillin.